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Dopamine and serotonin inversely modulate D2 medium spiny neurons to regulate cocaine reward.

Nat Commun · 2026 · PMC13133351 · PMID 41832154

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By contrast, mice with Htr2c loss-of-function in D2-MSNs showed a trend toward increased locomotor sensitization and exhibited an enhanced place preference for cocaine compared to Rosa26 controls (D2-sgHtr2c and D2-sgRosa, respectively; Fig. 3g–j ).

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