Lactate-Driven IL8+ Tumor-Associated Macrophages Mediate Immunosuppression and Resistance to Immunotherapy in Clear-Cell Renal Cell Carcinoma.

A comparable pattern in necrosis frequency was noted in the ZSHC cohort although the difference did not reach statistical significance (Supplementary Fig.

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Consistent associations were observed across external cohorts: higher IL8 levels showed a nonsignificant trend toward worse prognosis in the nivolumab-treated arm of the CheckMate cohort but a significant association in the atezolizumab plus bevacizumab arm of the IMmotion150 cohort, whereas no association was observed with everolimus (CheckMate) or sunitinib (IMmotion150) treatment (Supplementary Figs.

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