Prolyl-3-hydroxylase 1 is a central regulator of collagen post-translational modifications and the collagen biosynthetic network.

As β-actin showed a trend for upregulation in the KO animals, we additionally performed quantification of band intensities relative to cyclophilin B (PPIB), which confirmed upregulation of P3H2 and P3H3 protein levels in the P3h1 KO animals ( Fig.

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Of these, six were overhydroxylated in P3H1 KO mice (COL1A1 P322, P679, P760, P1108; COL1A2 P448, P544), and one showed a similar trend that failed to reach significance (COL1A1 P415).

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