Optimal 1TEL-target protein linker character is target protein-dependent.

Acta Crystallogr D Struct Biol · 2026 · PMC13133986 · PMID 41945409

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While flexible 10×His-1TEL-GG-DARPin and 10×His-1TELGGG-DARPin constructs exhibited similar crystallization speed and quality trends to the semi-flexible constructs above, the flexible linker constructs exhibited the opposite trend in crystallization propensity and a clear trend in crystal size, with the Gly-Gly linker resulting in larger crystals than the Gly-Gly-Gly linker.

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