Citrullinated histone H3 identifies neutrophil extracellular trap formation and correlates with renal disease activity in ANCA-associated vasculitis.

In the present study, comparison of renal function at the time of biopsy revealed a trend toward higher sCr levels and lower eGFR values in the H3Cit-positive group; however, these differences did not reach statistical significance between the two groups.

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In this subset, the H3Cit-positive group again showed significantly higher uβ 2 -MG and NAG index than did the negative group, whereas complement activity was lower only as a nonsignificant trend.

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