Targeting KIFC1 to disrupt centrosome clustering and trigger anaphase catastrophe in small-cell lung cancer.

Consistent with its link to proliferative activity, survival analysis in our institutional TMA cohort showed a trend toward shorter overall survival with increasing KIFC1 expression ( P = 0.021, log-rank test for trend; P = 0.053 for high vs. low groups; Supplemental Figure 4 ), suggesting that elevated KIFC1 expression may be associated with poor prognosis in SCLC.

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