New lens on congenital mild bone fragility: a novel Col1a1 knockout mouse model for osteogenesis imperfecta type 1.

COL1A1 expression only showed a trend toward reduction, which was not statistically significant due to donor variability, whereas COL1A2 exhibited a nonsignificant upward trend ( Figure 6A ).

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Statistically significant differences were identified for SGCA in iMSCs ( p = .0366) ( Figure S4D ), and for H1f9 ( p = .0362) and Sgca ( p = .0409) in BMSCs ( Figure S4A ), alongside an overall trend of increased expression in HI OI fibroblasts ( Figure S4C ).

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