FOSL2 regulates endothelial cell state and chromatin accessibility in systemic sclerosis pulmonary vascular remodeling.

JCI Insight · 2026 · PMC13135392 · PMID 42018656

Europe PMC DOI

hedged sentences

0.0800

closest p · 1.6× alpha

0.0800

boldest claim

The sentences

showed a trendP value = 0.08so close (0.05 < p ≤ 0.1)

Of these genes, only Jag2 showed a trend toward correlating with the patient mean pulmonary artery pressure ( r = 0.61, nominal P value = 0.08).

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highly significantno p-value reported

Both models showed strong, highly significant overlap with altered gene expression in SSc-ILD-PH versus healthy control lung ECs: 104 genes overlapped between the 2 models and SSc-ILD-PH (Monte Carlo simulation P = 0.0013, Supplemental Table 15 ).

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