Efficacy and safety of tyrosine kinase inhibitor combination therapy for glioblastoma: a meta-analysis with trial sequential analysis of randomized controlled trials.

Front Oncol · 2026 · PMC13135965 · PMID 42088219

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did not reach statistical significanceno p-value reported

Nevertheless, subgroup analyses revealed that these improvements in PFS and ORR did not reach statistical significance within the subgroups receiving TKIs combined with the Stupp regimen or with other non−standard therapies, nor when stratified by disease status (newly diagnosed versus recurrent GBM).

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