Integrative transcriptomic analysis reveals miR-26a-5p downregulation and a potential predictive gene signature for the progression of metabolic liver disease.

Moreover, although an integrative in silico analysis identified three downstream candidates of miR-26a-5p (EpCAM, DTNA, and KPNA2) that were consistently upregulated in MASLD and HCC and the protein expression analysis for EpCAM showed a trend consistent with our transcriptomic data, future studies will validate these axes biochemically, which will be essential to fully elucidate the regulatory network of miR-26a-5p in the context of diet-induced liver stress.

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