Cell and Nuclear Size Is Associated with Chromosomal Instability and Tumorigenicity in Cancer Cells That Undergo Whole Genome Doubling.

Consistent with a higher demand for proteins in the 4N compared with 2N cells, nascent polypeptide abundance (or total OPP fluorescence intensity) was higher in the S and L 4N clones than in the parental 2N cells across all cell lines, although this difference did not reach statistical significance in the DLD1 L 4N clones ( Fig. 4B–D ).

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