β-Sitosterol β-D-glucoside (BSSG) triggers intestinal inflammation in zebrafish and mouse models prior to neurodegeneration onset.

Overall, although these results did not reach statistical significance, likely due to the limited sample size, they suggest that BSSG treatment may influence the gut microbial composition, potentially contributing to the onset of dysbiosis.

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We observed a significant reduction in fkbp5 expression, while foxo3b displayed a decreasing trend in treated individuals (Fig. 6 D), further supporting our hypothesis.

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