Nfil3 integrates circadian rhythm and microbial metabolite signaling to maintain gut-liver immune-metabolic homeostasis under high-fat diet stress.

Notably, several KEGG “disease” or host-associated annotation categories (e.g., toxoplasmosis, small cell lung cancer, p53 signaling, influenza A, viral myocarditis, colorectal cancer) appeared among nominally significant features (all P ≈ 0.047) but displayed effect sizes close to zero.

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