HIF1-α induces mitochondrial fission in trophoblastic cells during early pregnancy and in preeclampsia.

iScience · 2026 · PMC13138064 · PMID 42088342

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did not reach statistical significanceno p-value reported

FIS1 also displayed a trend toward higher transcriptional and protein levels at 12–14 GW (+20%) compared to 7–9 GW ( Figures 3 B and 3C), although this did not reach statistical significance.

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a decreasing trendno p-value reported

Nevertheless, FIS1 overexpression in late-PE is not linked to HIF1-α stabilization based on our results obtained on chorionic villi at 7–9 GW and trophoblast exposed to CoCl 2 , in which FIS1 mRNA and protein levels showed a decreasing trend.

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