Advancements in Neonatal Brain Injury Treatment: Nanomedicine-Based Strategies.

For instance, a study using an ovine fetus hypoxia-ischemia model first demonstrated that systemic administration of MSC-EVs significantly improved cerebral electrophysiological function and showed a trend toward protecting myelination, highlighting their direct neuroprotective potential in a large neonatal animal model. 67 Subsequent research has focused on miRNAs carried by MSC-EVs, for example, Xin et al found that MSC-EVs deliver miR-21a-5p to microglia in the injured brain region. miR-21a-5p dri

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