Glycemic control targets in older adults with type 2 diabetes and chronic kidney disease: a trajectory-based survival analysis of glycated hemoglobin.

In contrast, although severe-declining patients reduced endpoint HbA1c to 6.72%, their mean HbA1c remained elevated (7.94%) due to extremely high baseline levels (9.00%), with mortality risk still showing an increasing trend (HR 1.50, 95% CI 0.95-2.37, p = .080).

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Although this association did not reach statistical significance, it suggests potential “legacy effects” of early sustained hyperglycemic exposure, whereby long-term adverse effects may persist even after subsequent glycemic improvement.

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