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Co-morbid biomarkers for sarcopenic obesity associated with gut microbiota metabolites: From burden to treatment.

PLoS Comput Biol · 2026 · PMC13138625 · PMID 42081471

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an increasing trendno p-value reported
Analysis of the CHARLS database (2011–2018), comprising approximately 20,000 individuals, revealed an increasing trend in the incidence of SO in China.

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Following an HFD intervention in mice, ALDH1A3 and CSF1R expression in muscle tissue was significantly upregulated, while PHGDH showed a consistent upward trend that did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.