Relationship of HOMA-IR with chronic kidney disease in diabetic and non-diabetic Chinese populations: findings from the REACTION study.

Given that there may be significant differences in metabolic profiles and CKD risk factors between ethnic groups, future validation of these findings in other ethnic populations and establishment of ethnic-specific threshold criteria are needed.

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Similarly, a Chinese study ( 31 ) found that CKD risk increased significantly across ascending quartiles of HOMA-IR among individuals with diabetes after adjustment for confounding factors (OR: 1.37, 95% CI: 1.07–1.74); however, this association did not reach statistical significance among those without diabetes (OR: 1.03, 95% CI: 0.89–1.20).

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