Potential efficacy and preliminary mechanistic insights of the Jianpi Yishen Zhuanggu Tongluo formula for rheumatoid arthritis with sarcopenia-osteopenia: an integrated pilot study.

Front Pharmacol · 2026 · PMC13139347 · PMID 42093870

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may be significantno p-value reported

Furthermore, the apparent regulation of multiple amino acid metabolism pathways (e.g., valine, leucine, isoleucine, glycine, serine, threonine, and particularly alanine, aspartate, glutamate, and arginine metabolism) may be significant.

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did not reach statistical significanceno p-value reported

The treatment group also showed improvement in the VAS score and skeletal muscle mass index (SMI) (P < 0.01, Figure 1A ), while the difference in VAS score in the control group before and after treatment did not reach statistical significance.

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