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Artificial intelligence-powered H&E-based quantification of spatial tumor-infiltrating lymphocyte distribution identifies prognostic immune niches in colorectal cancer.

Cancer Immunol Immunother · 2026 · PMC13139513 · PMID 42082707

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In the MSI-high subgroup, the TSB score retained significant prognostic stratification (HR = 0.10, 95% CI: 0.01–0.93, p = 0.013), whereas both the TIL score (HR = 0.31, 95% CI: 0.05–1.84, p = 0.171) and Immunoscore (HR = 0.40, 95% CI: 0.07–2.42, p = 0.305) did not reach statistical significance.

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