Shared genetic and neuroimmune architecture links type 1 diabetes with neurocognitive traits.

Nominally significant ( P < 0.05 but not meeting Bonferroni threshold P < 0.00238) included negative correlations with educational attainment and autism spectrum disorder and positive correlations with migraine, insomnia, and multiple sclerosis (Fig. 2a , and Supplementary Data 1 ).

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SCAVENGE confirmed persistent and robust enrichment of T1D heritability in microglia across all developmental stages (median TRS > 3.0–6.5) and additionally revealed highly significant, context-specific enrichment in inhibitory neurons (median TRS > 3) during the early postnatal and adult periods (Fig. 1b–e ).

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