Adipocyte-specific FFA2 deletion leads to increased adipose inflammation and is associated with altered intestinal lipid handling in mice.

Although this trend did not reach statistical significance ( p = 0.09 for the full day, p = 0.07 for the light period), it suggests a subtle shift in substrate utilization in Adipoq‐F2‐KO mice, with a greater reliance on glucose over fat as an energy source during rest periods.

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Additionally, there was a slight trend toward an increased RER in the Adipoq‐F2‐KO mice, particularly during the light/resting period, where the RER approached 1.0, suggesting a preference for carbohydrate metabolism over fat (Figure 4g ).

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