Lipid nanoparticle mRNA delivery preserves CAR T cell cytotoxicity and limits exhaustion compared to electroporation.

Mol Ther Nucleic Acids · 2026 · PMC13139981 · PMID 42095134

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During live-cell cytotoxicity assays, co-transfected T cells retained their enhanced migratory advantage and showed a trend toward improved killing of NALM6 target cells in the presence of CCL21 ( Figures 2 E and 2F), though with inter-donor variability in the magnitude of this effect ( Figure S2 A).

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