The skeletal muscle-adipose creatine metabolic axis: A novel paradigm for lipid metabolism reprogramming and obesity management.

Exp Physiol · 2026 · PMC13140267 · PMID 41071722

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0.1300

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did not reach statistical significanceP = 0.13not close (p > 0.1)

A 2019 meta‐analysis in adults ≥50 years old showed that creatine supplementation significantly reduced body fat percentage (−0.55%, P = 0.04), and although the reduction in absolute fat mass did not reach statistical significance (−0.50 kg, P = 0.13), the change may still be clinically relevant (Forbes et al., 2019 ).

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