White matter hyperintensities mediate a greater proportion of age-related lower cognitive scores in non-Hispanic White participants compared to non-Hispanic Black and Hispanic participants: HABS-HD.

However, for processing speed, the WMH × NHB interaction was modestly significant ( β = −0.06; 95% CI −0.10 to −0.01; p = 0.01), whereas the WMH × Hispanic interaction was not significant ( β = −0.01; 95% CI −0.05 to 0.03; p = 0.69).

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The WMH × NHB interaction did not reach statistical significance ( β = 0.04; 95% CI −0.01 to 0.08; p = 0.08), whereas the WMH × Hispanic interaction was significant ( β = 0.07; 95% CI 0.03 to 0.11; p < 0.01).

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