Associations between sleep disturbance and cerebrospinal fluid Aβ, and shared proteomic signatures in Alzheimer's disease.

Alzheimers Dement · 2026 · PMC13140711 · PMID 41912985

Europe PMC DOI

hedged sentences

0.0680

closest p · 1.4× alpha

0.3100

boldest claim

The sentences

marginally significantp = 0.068so close (0.05 < p ≤ 0.1)

Conversely, the ADE of sleep on Aβ42 was negative ( β = −15.88) and marginally significant ( p = 0.068).

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did not reach statistical significancep = 0.31not close (p > 0.1)

No evidence of interaction by cognitive impairment status was observed (likelihood ratio test, p > 0.05, Figure 3I ), indicating that the relationship between sleep disturbance and reduced Aβ42 levels did not differ between individuals with and without cognitive impairment, while analysis of the CSF Aβ42/40 ratio in an ADNI‐3 subsample ( n = 118) did not reach statistical significance ( p = 0.31; Figure S1 in supporting information), potentially due to the smaller sample size and restricted follow‐up compared to the primary cohort. 3.5.

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