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Neoadjuvant Therapy for Locally Advanced Gastric/Gastroesophageal Junction Adenocarcinoma: Current Status, Challenges, and Future Perspectives.

Cancer Med · 2026 · PMC13140983 · PMID 41876949

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an increasing trendno p-value reported
84.3%) in the apatinib plus chemotherapy group showed an increasing trend, no statistically significant differences were observed in these two indices between the two groups [ 97 ].

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showed a trendno p-value reported
Kohei Shitara from the National Cancer Center Hospital in Japan led the mid‐term results of the KEYNOTE‐585 study, and the final result demonstrated that neoadjuvant/adjuvant Pembrolizumab combined with FLOT is feasible in the perioperative treatment of locally advanced G/GEJ adenocarcinoma and showed a trend towards improved OS for patients [ 72 , 73 , 74 ].

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