Dissecting the Causal Pathway from Herpes Zoster to Postherpetic Neuralgia: A Multi-Stage Mendelian Randomization Study Implicating VZV-Specific IgE and Cerebrospinal Fluid Metabolites.

J Pain Res · 2026 · PMC13142265 · PMID 42093849

Europe PMC DOI

hedged sentence

0.0950

closest p · 1.9× alpha

0.0950

boldest claim

The sentences

nominally significantP = 0.095so close (0.05 < p ≤ 0.1)

Critically, 5-methyluridine—nominally significant in univariable analysis ( P = 0.095)—demonstrated a robust independent protective effect in MVMR (MV-IVW: β = −3.227, 95% CI: −5.765 to −0.688, FDR-adjusted P = 0.025; OR = 0.040).

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