Restoring the 14-3-3/CRAF regulatory interaction in Noonan syndrome using molecular glues.

Proc Natl Acad Sci U S A · 2026 · PMC13142914 · PMID 42048443

Europe PMC DOI

hedged sentence

0.0750

closest p · 1.5× alpha

0.0750

boldest claim

The sentences

did not reach statistical significanceP -value = 0.075so close (0.05 < p ≤ 0.1)

Although pERK tended to decrease upon treatment with 23 in the CRAF S257L background, the result did not reach statistical significance ( P -value = 0.075).

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.