Placental ferroptosis and impaired fetal growth in symptomatic and asymptomatic SARS-CoV-2 infections.

PLA2G6 also showed reduced expression in +Sx cases, though this did not reach statistical significance ( Figure 3 L)—suggesting reduced antioxidant capacity and increased susceptibility to oxidative stress in the placentas of male offspring.

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SARS-CoV-2 infection during pregnancy is associated with placental iron deposition and lipid peroxidation Compared with SARS-CoV-2− controls, placentas from SARS-CoV-2+ cases showed a notable trend toward elevated iron accumulation with a moderate effect size (Cohen’s d = 0.52) ( Figure 1 A,B) and no significant changes in 4-HNE levels ( Figure 1 D,E), a marker of lipid peroxidation.

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