NELFA-mediated pausing restrains YAP transcription and context-dependent outcomes in breast cancer.

Network enrichment analysis revealed a highly significant functional network (19 nodes, 29 edges; PPI enrichment p = 1.3e-12), with TNF emerging as the central hub ( Supplementary Figure 3G ).

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For disease-free survival, the ER-positive subtype showed an inverse association with NELFA expression, approaching significance ( Figure 3G ), but not in HER2-positive ( Figure 3H ) or TNBC ( Figure 3I ) subtypes. 3.10 YAP expression and its association with survival outcomes The same breast cancer cohort tumor samples were stained for YAP by IHC and scored by a certified pathologist, using the same grading system as for NELFA expression.

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