APOE ε4 as a predictor of cognitive decline and its interaction with hippocampal volume in Alzheimer's disease.

Front Aging Neurosci · 2026 · PMC13144130 · PMID 42100481

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hedged sentences

0.0010

closest p · 0.0× alpha

0.0710

boldest claim

The sentences

highly significantp < 0.001actually significant

The time × hippocampal volume interaction was confirmed as highly significant by likelihood ratio test (LR = 3712.99, p < 0.001).

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showed a trendp = 0.071so close (0.05 < p ≤ 0.1)

For ADAS-Cog13, the three-way interaction showed a trend in the same direction ( β = +1.29, 95% CI [−0.11, +2.69], p = 0.071) but did not meet the Bonferroni-corrected threshold.

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