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Human brain changes after first psilocybin use.

Nat Commun · 2026 · PMC13144397 · PMID 42086570

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In the present study, changes in brain network modularity failed to reach statistical significance (Fig. 2 ), but we did see a network modularity change vs mental health change relationship (Fig. 2D ) that was directionally consistent with previous work, i.e., decreased modularity correlating with improved mental health 28 .

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