Long-term dynamic effect of body mass index on adverse cardiovascular outcomes with targeted maximum likelihood estimation method: result from the KNOW-CKD study.

Although these associations did not reach statistical significance in the 3-year follow-up analysis (Supplementary Table S1 ), they became statistically significant over the 7 years follow-up period (HR 0.221, 95% CI 0.080–0.611; P = 0.004; Supplementary Table S2 ).

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