Polo-like kinase 5 is lowly expressed and negatively correlates with poorer differentiation, and its positivity may predict a better prognosis in patients with colorectal cancer.

Discov Oncol · 2026 · PMC13144467 · PMID 41893928

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did not reach statistical significanceno p-value reported

RFS tended to be greater in the PLK5-positive group than in the PLK5-negative expression group ( P = 0.077) and in the PLK5-high-expression group than in the PLK5-low-expression group ( P = 0.167), but the difference did not reach statistical significance.

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