Haloperidol induces neuroprotection and enhances neuromuscular function in both murine and human models of spinal muscular atrophy.

Exp Mol Med · 2026 · PMC13144737 · PMID 41974892

Europe PMC DOI

hedged sentences

0.0580

closest p · 1.2× alpha

0.0580

boldest claim

The sentences

borderline significantP = 0.058so close (0.05 < p ≤ 0.1)

By contrast, we observed a borderline significant increase in exon 8 inclusion (1,407-fold change; P = 0.058).

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did not reach statistical significanceno p-value reported

A trend toward increased SMN levels was also observed in the liver and heart of HALO-treated delta 7 mice with SMA, although this did not reach statistical significance (Supplementary Fig. 3 ).

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