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Impact of treatment discontinuation among patients with microsatellite instability or mismatch repair-deficient metastatic colorectal cancer treated with immune checkpoint inhibitors.

ESMO Open · 2026 · PMC13145382 · PMID 42066685

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Likewise, patients who progressed tended to have a higher number of metastatic sites compared with those who discontinued treatment because of toxicity or per protocol, although this did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.