ABSTRACT NUMBER: ESOC2026A1435 PRIME-IVT: FEASIBILITY AND EARLY EFFECTIVENESS OF A NATIONWIDE REGISTRY-EMBEDDED STEPPED-WEDGE CLUSTER RANDOMIZED TRIAL OF AN AUDIT-AND-FEEDBACK INTERVENTION TO IMPROVE INTRAVENOUS THROMBOLYSIS USE

Eur Stroke J · 2026 · PMC13145707

Europe PMC

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did not reach statistical significanceno p-value reported

Although the overall increase on IVT use did not reach statistical significance in this feasibility trial, the larger effect observed in highly engaged centers supports the need for a fully powered trial with enhanced strategies to maximize clinician engagement.

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