Exploring genomic analysis and methylome profiling in longitudinal series of p.G12C KRAS mutated NSCLC patients treated with sotorasib.

J Liq Biopsy · 2026 · PMC13146550 · PMID 42099550

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

a decreasing trendp-value = 0.07so close (0.05 < p ≤ 0.1)

1 A) whereas a decreasing trend was identified in ID#02,11 (median Δ = 12.1%) (p-value = 0.07).

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an increasing trendno p-value reported

In addition, an increasing trend between baseline and TP (0.4 vs 12.0; Δ = 11.5, from 0.2 to 54.9) was identified in 6 out of 17 (35.3%) NSCLC patients ( Table 2 ).

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did not reach statistical significanceno p-value reported

Setting the median MI as reference cut-off, an increased ORR was observed in patients with high vs low MI detected both at baseline (45.5% vs 18.2%, p:0.36) and at T1 (50.0% vs 22.2%, p: 0.44) timepoints, even if variations did not reach statistical significance ( Supplementary Figure 3 ).

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