Time-of-Day Immunotherapy Administration and Outcomes in Advanced Cancers: A Systematic Review and Meta-Analysis.

JAMA Netw Open · 2026 · PMC13147196 · PMID 42084869

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closest p

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did not reach statistical significanceno p-value reported

Analysis limited to studies with unadjusted HRs 25 , 33 , 36 , 40 showed a similar direction of association, which did not reach statistical significance (HR, 0.76; 95% CI, 0.57-1.02) (eFigure 5 in Supplement 1 ).

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