Genetically predicted TTK inhibition and its association with reduced breast cancer risk: a two-step Mendelian randomization study of potential gut microbiome mediation.

Exploratory mediation analysis of a nominally significant taxon Although no microbial taxa showed a statistically significant association with both TTK inhibition and BC after FDR correction, the authors conducted a purely exploratory analysis on Genus Anaerostipes id.1991, which showed the strongest nominal signals in both steps (TTK inhibition → Anaerostipes : OR = 1.399, 95 % CI 1.117‒1.753, uncorrected p = 0.003; Anaerostipes → BC: OR = 0.862, 95 % CI 0.757‒0.982, uncorrected p = 0.025).

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