Dynamic platelet profiles in the emergency department and their predictive value for 28-day all-cause mortality in septic patients.

After additional adjustment for baseline disease severity markers and platelet count in Model 3, the associations remained highly significant (intermediate: aHR = 2.70, 95% CI: 1.60–4.59, p < 0.001; late: aHR = 6.33, 95% CI: 3.42–11.70, p < 0.001).

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In investigating the relationship between platelet parameters and mortality in sepsis, we unexpectedly observed in univariable Cox analysis that Gram-positive and Gram-negative bacterial detection was associated with reduced mortality, whereas other pathogens (including fungi, viruses, and atypical organisms) showed a trend toward increased mortality (HR 1.45, Table 2 ).

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