Impact of physical and chemical parameters on spinoculation for chimeric antigen receptor T cell manufacturing using a quality-by-design approach.

Although the volume ( Figure 2 E) and cell concentration ( Figure 2 F) at which spinoculation was performed did not lead to changes in the CD4:CD8 (1.5 ± 0.4 and 1.4 ± 0.3, respectively), increasing the spinoculation speed showed a trend toward a higher ratio ( Figure 2 G).

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