Autophagy activation via BAG3 gene therapy improves phenotype in a mouse model of LGMD1A.

In addition, we assessed the levels HSPB8 protein, which is known to interact with BAG3 and facilitate the autophagic process as part of the ALP, 22 , 23 and as expected, BAG3 treatment resulted in a strong trend toward increased HSPB8 protein levels ( p = 0.076) in muscle ( Figure 6 D).

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UT, 5.19 ± 0.64 mN∗m, n = 8; p = 0.047; WT, 13.46 ± 0.92 mN∗m, n = 5, Figure 2 D), while we observed an increasing trend for maximum twitch response that did not reach significance (BAG3, 1.59 ± 0.45 mN∗m, n = 8; vs.

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