Factors affecting trough concentrations of voriconazole: a dual-center retrospective analysis focusing on loading dose and inflammatory state effects.

Although the effect of isoniazid ( p = 0.065) did not reach statistical significance, its coefficient was negative, suggesting a potential trend toward reduced concentrations in patients not using isoniazid. 3.4 ROC curve analysis of predictive factors ROC curve analysis was used to evaluate the performance of various continuous variables in predicting whether the VCZ plasma concentration reached the target level ( Figure 4 ).

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