Clinical experience using trofinetide in Rett syndrome and related MECP2 diagnosis at the children's hospital of Philadelphia post approval.

Front Neurol · 2026 · PMC13149144 · PMID 42111068

Europe PMC DOI

hedged sentence

0.7910

closest p · 15.8× alpha

0.7910

boldest claim

The sentences

did not reach statistical significancep = 0.791not close (p > 0.1)

Similarly, at 6 months, the moderate group showed the highest mean improvement (−6.14, SD = 9.35), followed by the mild group (−4.29, SD = 8.64) and the severe group (−3.00, SD = 9.14), but again, these differences did not reach statistical significance [ F (2, 20) = 0.24, p = 0.791, η 2 = 0.023].

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