Intracerebroventricular diphtheria toxin causes off-target toxicity in CD11b-DTR and wild-type mice, revealing limitations of DTR-based depletion studies.

Front Neurosci · 2026 · PMC13149294 · PMID 42110194

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hedged sentence

0.0505

closest p · 1.0× alpha

0.0505

boldest claim

The sentences

approached significancep = 0.0505so close (0.05 < p ≤ 0.1)

Consistent with this, the effect in WT mice approached significance ( p = 0.0505), hinting at possible subtle alterations in activity at higher doses.

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