Integrative clinical and genomic analyses reveal a causal role of GPNMB in the bone-brain axis of Parkinson's disease.

NPJ Parkinsons Dis · 2026 · PMC13150002 · PMID 41851136

Europe PMC DOI

hedged sentence

0.0620

closest p · 1.2× alpha

0.0620

boldest claim

The sentences

did not reach statistical significanceP = 0.062so close (0.05 < p ≤ 0.1)

In additional sex-stratified analyses, plasma GPNMB levels remained significntly elevated in female PD patients (Padj = 0.031), whereas the increase did not reach statistical significance in males ( P = 0.062, Padj = 0.252).

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.