Reply to: Is the role of eosinophils in refractory chronic cough truly dismissed? Mepolizumab reduced blood and sputum eosinophils, but not eosinophil-derived neurotoxin.

Eur Respir J · 2026 · PMC13150355 · PMID 42097671

Europe PMC DOI

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0.0540

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0.0540

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The sentences

showed a trendp=0.054so close (0.05 < p ≤ 0.1)

While mepolizumab treatment also reduced the frequency of sputum eosinophils expressing the activation marker CD69 (p=0.0008) and showed a trend towards a reduction in the frequency of blood eosinophils expressing CCR3 and CD66b (p=0.054 and p=0.052, respectively), the functional significance of these changes is currently unknown.

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