Korean Society of Heart Failure Guidelines for the Palliative Care and Hospice for Heart Failure Patients.

In two randomized controlled trials using MADRS, antidepressant-treated patients demonstrated a trend toward increased response at 14 days (RR, 2.16; 95% CI, 0.74 to 6.27), although this did not reach statistical significance. 86 , 87) In a single randomized trial using HADS-D, a modest reduction of 1.3 points (median, −1.30; 95% CI, −2.10 to −0.50) was reported. 87) A 1.7-point reduction in ESAS-depression was also observed in one study, 88) although the limited number of trials prevents firm conclusions.

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